Advances in biomathematical modeling for PET neuroreceptor imaging

Roger N Gunn; Qi Guo; Cristian A Salinas; Andri C Tziortzi; Graham E Searle

doi:10.1016/j.ddtec.2012.01.001

Advances in biomathematical modeling for PET neuroreceptor imaging

Drug Discov Today Technol. 2011 Summer;8(2-4):e45-51. doi: 10.1016/j.ddtec.2012.01.001.

Authors

Roger N Gunn¹, Qi Guo², Cristian A Salinas³, Andri C Tziortzi⁴, Graham E Searle³

Affiliations

¹ Department of Medicine, Imperial College London, London, UK. Electronic address:roger.gunn@imanova.co.uk.
² Department of Medicine, Imperial College London, London, UK.
³ Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK.
⁴ FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, UK.

PMID: 24990262
DOI: 10.1016/j.ddtec.2012.01.001

Abstract

The quantitative application of PET neuroreceptor imaging to study pathophysiology, diagnostics and drug development has continued to benefit from associated advances in biomathematical imaging methodology. We review some of these advances with particular focus on multi-modal image processing, tracer kinetic modeling, occupancy studies and discovery and development of novel radioligands.: