Abstract
The pseudoparticle virus neutralisation test (ppNT) and a conventional microneutralisation (MN) assay are specific for detecting antibodies to Middle East respiratory syndrome coronavirus (MERS-CoV) when used in seroepidemiological studies in animals. Genetically diverse MERS-CoV appear antigenically similar in MN tests. We confirm that MERS-CoV was circulating in dromedaries in Saudi Arabia in 1993. Preliminary data suggest that feral Australian dromedaries may be free of MERS-CoV but larger confirmatory studies are needed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Neutralizing / blood*
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Antibodies, Viral / blood*
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Australia / epidemiology
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Camelus / blood*
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Cattle / blood
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Coronavirus / immunology*
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Coronavirus / isolation & purification
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Coronavirus Infections / blood
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Coronavirus Infections / epidemiology*
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Coronavirus Infections / virology
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Humans
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Immunoglobulin G / blood
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Neutralization Tests / methods*
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Prevalence
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Respiratory Tract Infections / blood
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Respiratory Tract Infections / epidemiology*
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Respiratory Tract Infections / virology
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Saudi Arabia / epidemiology
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Seroepidemiologic Studies
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Immunoglobulin G