Aneuploidy and tumorigenesis in Drosophila

Marco Milán; Marta Clemente-Ruiz; Andrés Dekanty; Mariana Muzzopappa

doi:10.1016/j.semcdb.2014.03.014

Aneuploidy and tumorigenesis in Drosophila

Semin Cell Dev Biol. 2014 Apr:28:110-5. doi: 10.1016/j.semcdb.2014.03.014. Epub 2014 Mar 15.

Authors

Marco Milán¹, Marta Clemente-Ruiz², Andrés Dekanty², Mariana Muzzopappa²

Affiliations

¹ ICREA, Spain; Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac, 10-12, 08028 Barcelona, Spain. Electronic address: marco.milan@irbbarcelona.org.
² Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac, 10-12, 08028 Barcelona, Spain.

PMID: 24641887
DOI: 10.1016/j.semcdb.2014.03.014

Abstract

Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative epithelial cells. However, the causal relationship between aneuploidy and tumorigenesis remains highly debated. On the one hand, aneuploidy has been shown to be a powerful driver of tumor progression, anticancer drug resistance, and tumor relapse. On the other hand, aneuploidy causes proteotoxic and metabolic stress, which compromises cell cycle proliferation and growth. Here we discuss the role of aneuploidy in tumorigenesis in light of the contribution of Drosophila epithelial cancer models and propose a stress-induced tumor-promoting role of aneuploidy.

Keywords: CIN; Delamination; JNK; MMP1; Stress; Wingless; p53.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aneuploidy*
Animals
Carcinogenesis / genetics*
Cell Cycle / genetics*
Cell Proliferation / genetics
Cell Proliferation / physiology
Cell Transformation, Neoplastic / genetics*
Chromosomal Instability / physiology*
Drosophila
Humans