Adsorption and desorption behaviors of selected endocrine disrupting chemicals in simulated gastrointestinal fluids

Mar Pollut Bull. 2014 Aug 30;85(2):363-9. doi: 10.1016/j.marpolbul.2014.01.047. Epub 2014 Feb 15.

Abstract

An in vitro technique using simulated gastrointestinal (GI) fluids was applied to investigate the desorption of selected endocrine disrupting chemicals (EDCs), i.e. bisphenol A (BPA) and 17 α-ethinylestradiol (EE2), from the marine sediment in the digestive environment. The results show that the GI fluids suppressed chemical adsorption and greatly increased the desorption of BPA and EE2 from the sediment. Pepsin in the gastric fluid would compete for the adsorption sites with the adsorbates, and bile salts in the intestinal fluid had a solubilization effect on the chemicals. The amount of chemical release from the sediment in different fluids followed intestinal (fed)>intestinal (fasted)>gastric>saline water. During the dynamic desorption tests, 62% and 21% of sediment-bound BPA and EE2, respectively, could be released into the simulated GI fluids. The enhanced desorption of EDCs from sediment in the digestive system would make the pollutants more bioavailable in the ecosystem.

Keywords: 17 α-Ethinylestradiol (EE2); Adsorption; Bisphenol A (BPA); Desorption; Gastrointestinal fluids; Marine sediment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Benzhydryl Compounds / analysis
  • Benzhydryl Compounds / chemistry*
  • Endocrine Disruptors / analysis
  • Endocrine Disruptors / chemistry*
  • Ethinyl Estradiol / analysis
  • Ethinyl Estradiol / chemistry*
  • Gastrointestinal Contents / chemistry
  • Geologic Sediments / chemistry
  • Phenols / analysis
  • Phenols / chemistry*
  • Water
  • Water Pollutants, Chemical / analysis
  • Water Pollutants, Chemical / chemistry*

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • Water Pollutants, Chemical
  • Water
  • Ethinyl Estradiol
  • bisphenol A