Detection of neovascularization based on fractal and texture analysis with interaction effects in diabetic retinopathy

PLoS One. 2013 Dec 16;8(12):e75699. doi: 10.1371/journal.pone.0075699. eCollection 2013.

Abstract

Diabetic retinopathy is a major cause of blindness. Proliferative diabetic retinopathy is a result of severe vascular complication and is visible as neovascularization of the retina. Automatic detection of such new vessels would be useful for the severity grading of diabetic retinopathy, and it is an important part of screening process to identify those who may require immediate treatment for their diabetic retinopathy. We proposed a novel new vessels detection method including statistical texture analysis (STA), high order spectrum analysis (HOS), fractal analysis (FA), and most importantly we have shown that by incorporating their associated interactions the accuracy of new vessels detection can be greatly improved. To assess its performance, the sensitivity, specificity and accuracy (AUC) are obtained. They are 96.3%, 99.1% and 98.5% (99.3%), respectively. It is found that the proposed method can improve the accuracy of new vessels detection significantly over previous methods. The algorithm can be automated and is valuable to detect relatively severe cases of diabetic retinopathy among diabetes patients.

MeSH terms

  • Algorithms
  • Diabetic Retinopathy / diagnosis*
  • Diabetic Retinopathy / pathology
  • Fractals
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Neovascularization, Pathologic / diagnosis*
  • Neovascularization, Pathologic / pathology
  • Retinal Vessels / pathology*

Grants and funding

The authors have no support or funding to report.