A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation

Chun Ling Tung; Hiu Yung Lam; Jianchao Xu; Xuechen Li

doi:10.1039/c3cc47465h

A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation

Chem Commun (Camb). 2014 May 25;50(40):5298-300. doi: 10.1039/c3cc47465h. Epub 2013 Nov 6.

Authors

Chun Ling Tung¹, Hiu Yung Lam, Jianchao Xu, Xuechen Li

Affiliation

¹ Department of Chemistry, The University of Hong Kong, Hong Kong, P. R. China. xuechenl@hku.hk.

PMID: 24192710
DOI: 10.1039/c3cc47465h

Abstract

The 5-lysyl-hydroxylation has been found among protein post-translational modifications. In this report, we have devised a fluorescence turn-on probe which allows for selectively recognizing 5-hydroxylysine-containing peptides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fluorescent Dyes / chemistry*
Hydroxylysine / chemistry*
Peptide Fragments / chemistry*
Proteins / chemistry*
Serine / chemistry*
Threonine / chemistry*

Substances

Fluorescent Dyes
Peptide Fragments
Proteins
Hydroxylysine
Threonine
Serine