Abstract
Embedded in a polymer: A hydrophobic organic molecule that fluoresces in the near-infrared II (NIR-II) region was made water-soluble and biocompatible by its embedment in a polymer nanoparticle, which was then coated with hydrophilic poly(ethylene glycol) chains. The resulting nanoparticles exhibit bright fluorescence in the NIR-II window and high photostability in aqueous media and were used for in vivo imaging in mice.
Keywords:
fluorescence; imaging agents; nanoparticles; near infrared; polymers.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemistry
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Animals
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Fluorescent Dyes / chemistry*
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Mice
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Mice, Nude
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Microscopy, Atomic Force
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Nanoparticles / chemistry*
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Phosphatidylethanolamines / chemistry
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Polyethylene Glycols / chemistry
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Polymers / chemistry*
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Spectroscopy, Near-Infrared / methods*
Substances
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Acrylic Resins
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Biocompatible Materials
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Fluorescent Dyes
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Phosphatidylethanolamines
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Polymers
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polyethylene glycol-distearoylphosphatidylethanolamine
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Polyethylene Glycols