Abstract
The sensing of viral RNA by the host innate immune system is mediated by RIG-I and its partner PACT. In this issue of Cell Host & Microbe, Luthra et al. (2013) show that the Ebola virus VP35 protein counteracts the action of PACT at the cost of compromising its own function in viral replication.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
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DEAD Box Protein 58
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DEAD-box RNA Helicases / metabolism*
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Ebolavirus / metabolism*
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Hemorrhagic Fever, Ebola / metabolism*
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Humans
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RNA-Binding Proteins / metabolism*
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Receptors, Immunologic
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Viral Regulatory and Accessory Proteins / metabolism*
Substances
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PRKRA protein, human
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RNA-Binding Proteins
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Receptors, Immunologic
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VP35 protein, filovirus
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Viral Regulatory and Accessory Proteins
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RIGI protein, human
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DEAD Box Protein 58
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DEAD-box RNA Helicases