Balance of power in host-virus arms races

Cell Host Microbe. 2013 Jul 17;14(1):5-6. doi: 10.1016/j.chom.2013.07.004.

Abstract

The sensing of viral RNA by the host innate immune system is mediated by RIG-I and its partner PACT. In this issue of Cell Host & Microbe, Luthra et al. (2013) show that the Ebola virus VP35 protein counteracts the action of PACT at the cost of compromising its own function in viral replication.

Publication types

  • Comment

MeSH terms

  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / metabolism*
  • Ebolavirus / metabolism*
  • Hemorrhagic Fever, Ebola / metabolism*
  • Humans
  • RNA-Binding Proteins / metabolism*
  • Receptors, Immunologic
  • Viral Regulatory and Accessory Proteins / metabolism*

Substances

  • PRKRA protein, human
  • RNA-Binding Proteins
  • Receptors, Immunologic
  • VP35 protein, filovirus
  • Viral Regulatory and Accessory Proteins
  • RIGI protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases