Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors

Hong Kong Med J. 2013 Jun:19 Suppl 4:29-35.

Abstract

1. Cyclooxygenase-2 (COX-2), along with TNF-α and other proinflammatory cytokines, was hyperinduced in H5N1- infected macrophages in vitro and in epithelial cells of autopsied lung tissues of infected patients. 2. The COX-2 mediated amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. 3. Selective COX-2 inhibitors suppress the H5N1- hyperinduced cytokines in the proinflammatory cascade.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cell Line, Tumor
  • Cyclooxygenase 2 / drug effects
  • Cyclooxygenase 2 Inhibitors / pharmacology*
  • Cytokines / metabolism
  • Epithelial Cells / metabolism
  • Epithelial Cells / virology
  • Humans
  • Inflammation / drug therapy
  • Inflammation / virology
  • Influenza A Virus, H5N1 Subtype / drug effects
  • Influenza A Virus, H5N1 Subtype / enzymology*
  • Influenza A Virus, H5N1 Subtype / isolation & purification
  • Influenza, Human / drug therapy
  • Influenza, Human / enzymology*
  • Influenza, Human / virology
  • Lung / cytology
  • Lung / virology
  • Macrophages / metabolism
  • Macrophages / virology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Antiviral Agents
  • Cyclooxygenase 2 Inhibitors
  • Cytokines
  • Tumor Necrosis Factor-alpha
  • Cyclooxygenase 2