Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking

Tianfan Cheng; Hongyan Li; Xinming Yang; Wei Xia; Hongzhe Sun

doi:10.1039/c3mt00014a

Interaction of SlyD with HypB of Helicobacter pylori facilitates nickel trafficking

Metallomics. 2013 Jun;5(7):804-7. doi: 10.1039/c3mt00014a.

Authors

Tianfan Cheng¹, Hongyan Li, Xinming Yang, Wei Xia, Hongzhe Sun

Affiliation

¹ Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.

PMID: 23708681
DOI: 10.1039/c3mt00014a

Abstract

SlyD from Helicobacter pylori interacts with the [NiFe] hydrogenase accessory protein HypB through its IF domain. HpSlyD delivers Ni(2+) to HpHypB, leading to the enhancement of GTPase activity of HpHypB and implying the facilitation of Ni(2+) delivery from HpHypB to [NiFe] hydrogenase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / metabolism*
GTP-Binding Proteins / metabolism*
Green Fluorescent Proteins / metabolism
Helicobacter pylori / metabolism*
Hydrogenase / metabolism
Ion Transport
Nickel / metabolism*
Nuclear Magnetic Resonance, Biomolecular

Substances

Bacterial Proteins
HypB protein, bacteria
Green Fluorescent Proteins
Nickel
nickel-iron hydrogenase
Hydrogenase
GTP-Binding Proteins