Association between MMP-1 g.-1607dupG polymorphism and periodontitis susceptibility: a meta-analysis

PLoS One. 2013;8(3):e59513. doi: 10.1371/journal.pone.0059513. Epub 2013 Mar 20.

Abstract

Background: Matrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.

Methods: Retrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and periodontitis susceptibility were included into the final analysis with definite selection and exclusion criteria. Overall and stratified analyses based on disease type, severity, ethnicity and smoking status were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between MMP-1 g.-1607dupG and periodontitis susceptibility, while Q test and Egger's test were adopted respectively to assess heterogeneity among studies and publication bias.

Results: A total of 1580 periodontitis cases and 1386 controls in 11 case-control studies were included in the meta-analysis. The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR = 1.50, 95% CI = 1.02-2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR = 1.28, 95% CI = 1.04-1.57). For subgroups by type of periodontitis, increased risk of chronic periodontitis was observed on heterozygote (2G/1G versus 1G/1G, OR = 2.01, 95% CI = 1.58-2.56) and dominant model (OR = 1.27, 95% CI = 1.03-1.57). Furthermore, similar association was also detected in severe chronic periodontitis (2G/2G versus 1G/1G, OR = 2.15, 95% CI = 1.35-3.43; 2G/2G+2G/1G versus 1G/1G, OR = 1.64, 95% CI = 1.12-2.39; 2G/2G versus 2G/1G+1G/1G, OR = 1.86, 95% CI = 1.31-2.64).

Conclusions: Our meta-analysis demonstrated that MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Linear Models
  • Matrix Metalloproteinase 1 / genetics*
  • Models, Statistical
  • Odds Ratio
  • Periodontitis / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Publication Bias

Substances

  • Matrix Metalloproteinase 1

Grants and funding

This study was supported in part by the National Natural Science Foundation of China (30973361, 81170981 and 81000457), Natural Science Foundation of JiangSu Province (81000457), Natural Science Foundation for Colleges and Universities in JiangSu Province (10kJB320004), Project of State Key Laboratory of Oral Diseases (SKLODSCU2009KF05) and Project Funded by the Priority Academic Program Development of JiangSu Higher Education Institutions (PAPD). The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.