A silver complex of N,N'-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase

Chem Commun (Camb). 2013 Apr 25;49(32):3297-9. doi: 10.1039/c3cc00063j.

Abstract

A silver complex of N,N'-disubstituted cyclic thiourea inhibits inflammatory cytokine-stimulated NF-κB activity via IκB kinase inactivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • HeLa Cells
  • Humans
  • I-kappa B Kinase / antagonists & inhibitors*
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / genetics
  • Protein Kinase Inhibitors / chemistry
  • Silver / chemistry
  • Silver / pharmacology*
  • Thiourea / chemistry
  • Thiourea / pharmacology*
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Anti-Inflammatory Agents
  • NF-kappa B
  • Protein Kinase Inhibitors
  • Tumor Necrosis Factor-alpha
  • Silver
  • I-kappa B Kinase
  • Thiourea