Hyperthyroidism during pregnancy due to coexistence of struma ovarii and Graves' disease

Postgrad Med J. 1990 Feb;66(772):132-3. doi: 10.1136/pgmj.66.772.132.

Abstract

A patient with hyperthyroid Graves' disease and struma ovarii is described. She had pre-existing Graves' disease and positive thyrotrophin receptor antibody. She was treated with radioactive iodine 5 months before she became pregnant. Paripartum she had torsion of an ovarian cyst with histological evidence of a functional struma ovarii. Immediate exacerbation of her thyrotoxic state was observed after operation as a result of release of thyroid hormone from the tumour. It is postulated that the tumour was stimulated by circulating thyrotrophin receptor antibody.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies / analysis
  • Female
  • Graves Disease / complications*
  • Graves Disease / radiotherapy
  • Humans
  • Hyperthyroidism / etiology*
  • Iodine Radioisotopes / therapeutic use
  • Ovarian Neoplasms / complications*
  • Pregnancy
  • Pregnancy Complications*
  • Pregnancy Complications, Neoplastic*
  • Receptors, Thyrotropin / immunology
  • Struma Ovarii / complications*

Substances

  • Antibodies
  • Iodine Radioisotopes
  • Receptors, Thyrotropin