Reduced serum beta-trace protein is associated with metabolic syndrome

Atherosclerosis. 2013 Apr;227(2):404-7. doi: 10.1016/j.atherosclerosis.2013.01.008. Epub 2013 Jan 17.

Abstract

Objectives: β-trace protein (BTP), also known as lipocalin-type prostaglandin D2 synthase, has shown to regulate glucose and lipid metabolism in vivo. We sought to study the relationship of serum BTP with diabetes and metabolic syndrome (MetS).

Methods: Data on 3136 participants aged ≥20 years of the National Health and Nutrition Examination Survey III were examined. Logistic regression was used to assess the association of BTP with diabetes and MetS.

Results: Reduced levels of BTP were associated with diabetes and MetS in age, sex, and race/ethnicity adjusted models. After further multivariable adjustment, BTP levels in quartile 1 remained significantly associated with MetS (odds ratio 2.04 [95% CI 1.14-3.70], Ptrend = 0.003) when compared with quartile 4. Among the five components of MetS, BTP was associated with hypertriglyceridemia (Ptrend < 0.001) but not diabetes (Ptrend = 0.099).

Conclusion: MetS is associated with a reduced serum level of BTP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Cross-Sectional Studies
  • Diabetes Mellitus / blood
  • Female
  • Glucose / metabolism
  • Humans
  • Intramolecular Oxidoreductases / blood*
  • Lipid Metabolism
  • Lipocalins / blood*
  • Male
  • Metabolic Syndrome / blood*
  • Middle Aged
  • Multivariate Analysis
  • Nutrition Surveys
  • Regression Analysis
  • United States

Substances

  • Biomarkers
  • Lipocalins
  • Intramolecular Oxidoreductases
  • prostaglandin R2 D-isomerase
  • Glucose