Increased ectopic action potential generation accompanies epileptogenesis in vitro

S F Stasheff; W A Wilson

doi:10.1016/0304-3940(90)90359-h

Increased ectopic action potential generation accompanies epileptogenesis in vitro

Neurosci Lett. 1990 Mar 26;111(1-2):144-50. doi: 10.1016/0304-3940(90)90359-h.

Authors

S F Stasheff¹, W A Wilson

Affiliation

¹ Department of Medicine, Duke University, Durham, NC.

PMID: 2336180
DOI: 10.1016/0304-3940(90)90359-h

Abstract

We studied changes in the characteristics of action potentials of CA3 pyramidal cells accompanying electrographic seizure (EGS) induction, using an in vitro model similar to kindling. We found an increased propensity to fire action potentials which lack EPSPs or other triggering depolarizing potentials. Such 'baseline spikes' appear to be initiated at a site electrically distant from the soma.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Action Potentials
Animals
Electric Stimulation
Epilepsy / physiopathology*
Hippocampus / physiopathology*
In Vitro Techniques

Grants and funding

NS 17771/NS/NINDS NIH HHS/United States