Metabolism and the circadian clock converge

Physiol Rev. 2013 Jan;93(1):107-35. doi: 10.1152/physrev.00016.2012.

Abstract

Circadian rhythms occur in almost all species and control vital aspects of our physiology, from sleeping and waking to neurotransmitter secretion and cellular metabolism. Epidemiological studies from recent decades have supported a unique role for circadian rhythm in metabolism. As evidenced by individuals working night or rotating shifts, but also by rodent models of circadian arrhythmia, disruption of the circadian cycle is strongly associated with metabolic imbalance. Some genetically engineered mouse models of circadian rhythmicity are obese and show hallmark signs of the metabolic syndrome. Whether these phenotypes are due to the loss of distinct circadian clock genes within a specific tissue versus the disruption of rhythmic physiological activities (such as eating and sleeping) remains a cynosure within the fields of chronobiology and metabolism. Becoming more apparent is that from metabolites to transcription factors, the circadian clock interfaces with metabolism in numerous ways that are essential for maintaining metabolic homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / physiopathology
  • Circadian Rhythm Signaling Peptides and Proteins / genetics
  • Circadian Rhythm Signaling Peptides and Proteins / metabolism*
  • Circadian Rhythm* / genetics
  • Energy Metabolism* / genetics
  • Enzymes / metabolism
  • Gene Expression Regulation
  • Homeostasis
  • Humans
  • Neural Pathways / metabolism
  • Neural Pathways / physiopathology
  • Sleep Disorders, Circadian Rhythm / metabolism
  • Sleep Disorders, Circadian Rhythm / physiopathology
  • Sleep* / genetics
  • Wakefulness* / genetics

Substances

  • Circadian Rhythm Signaling Peptides and Proteins
  • Enzymes