Characterization of tyrosinase inhibitors in the twigs of Cudrania tricuspidata and their structure-activity relationship study

Zong-Ping Zheng; Hui-Yuan Tan; Jie Chen; Mingfu Wang

doi:10.1016/j.fitote.2012.12.006

Characterization of tyrosinase inhibitors in the twigs of Cudrania tricuspidata and their structure-activity relationship study

Fitoterapia. 2013 Jan:84:242-7. doi: 10.1016/j.fitote.2012.12.006. Epub 2012 Dec 20.

Authors

Zong-Ping Zheng¹, Hui-Yuan Tan, Jie Chen, Mingfu Wang

Affiliation

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu, PR China.

PMID: 23262271
DOI: 10.1016/j.fitote.2012.12.006

Abstract

The twigs of Cudrania tricuspidata were found to show strong tyrosinase inhibitory activity, and further detailed component analysis resulted in the isolation of a new flavanol glucoside, (2S,3S)-2,3-trans-dihydromorin-7-O-β-d-glucoside (1), plus twenty-seven known compounds (2-28). Their structures were elucidated on the basis of ESI-MS and NMR spectral data. Among the isolated compounds, trans-dihydromorin (8), oxyresveratrol (9), and steppogenin (12) were found to exhibit significant tyrosinase inhibition activities. Moreover, the structure-activity relationship of these isolated compounds was also discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Molecular Structure
Monophenol Monooxygenase / antagonists & inhibitors*
Moraceae / chemistry*
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Monophenol Monooxygenase