Fluoride and silver concentrations of silver diammine fluoride solutions for dental use

Int J Paediatr Dent. 2013 Jul;23(4):279-85. doi: 10.1111/ipd.12005. Epub 2012 Oct 3.

Abstract

Objective: To determine the short-term stability of free fluoride ion concentrations and acidity (pH values) of three commercially available SDF solutions over time.

Methods: Three SDF products for caries control were studied: Cariestop-12%, Cariestop-30% and Saforide-38%. Their expected fluoride ion concentrations were 14,200, 35,400 and 44,800 ppm, respectively. The fluoride ion concentrations were determined with an ion-selective electrode. The acidity was determined with a pH electrode. The measurements were performed when open and at 7 and 28 days.

Results: The mean fluoride ion concentrations of the freshly opened bottles were 12,525 ± 450, 13,200 ± 2060 and 55,800 ± 2536 ppm, respectively. The mean pH values were 9.4 ± 0.1, 10.4 ± 0.1 and 10.2 ± 0.2, respectively. No significant change (P > 0.05) in the fluoride ion concentrations or the acidity was detected after 7 or 28 days.

Conclusion: The three SDF tested solutions were alkaline. The fluoride ion concentrations of Cariestop-30% and Saforide-38% were considerably different. The fluoride ion concentrations and acidity of the products demonstrated a short-term stability over 28 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cariostatic Agents / chemistry*
  • Drug Stability
  • Fluorides / analysis*
  • Fluorides, Topical
  • Humans
  • Hydrogen-Ion Concentration
  • Ion-Selective Electrodes
  • Materials Testing
  • Quaternary Ammonium Compounds / chemistry*
  • Silver / analysis*
  • Silver Compounds
  • Time Factors

Substances

  • Cariostatic Agents
  • Fluorides, Topical
  • Quaternary Ammonium Compounds
  • Silver Compounds
  • Silver
  • silver diamine fluoride
  • Fluorides