Label-free sensing of pH and silver nanoparticles using an "OR" logic gate

Anal Chim Acta. 2012 Jul 6:733:78-83. doi: 10.1016/j.aca.2012.04.041. Epub 2012 May 10.

Abstract

Many natural phenomena are associated with the presence of two or more separate variables. We report here an "OR" DNA logic gate based on a luminescent platinum(II) switch-on probe for silver nanoparticles and pH, both of which may be considered putative indicators of pollution. The modulation of metal complex/double-stranded DNA complex phosphorescence by Ag(+) and H(+) was used to construct a simple, rapid and label-free method for the label-free detection of pH and nanomolar Ag(+) ions and nanoparticles in aqueous solutions with high selectivity.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cations, Monovalent / analysis
  • DNA / chemistry*
  • Hydrogen-Ion Concentration
  • Luminescent Agents / chemistry*
  • Luminescent Measurements / methods*
  • Nanoparticles / analysis*
  • Organoplatinum Compounds / chemistry*
  • Sensitivity and Specificity
  • Silver / analysis*

Substances

  • Cations, Monovalent
  • Luminescent Agents
  • Organoplatinum Compounds
  • Silver
  • DNA