New ruthenium(II) complexes functionalized with coumarin derivatives: synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies

Chemistry. 2012 Jul 9;18(28):8724-30. doi: 10.1002/chem.201103025. Epub 2012 Jun 12.

Abstract

Two new bichromophoric ruthenium(II) complexes, [Ru(bpy)(2)(bpy-CM)](PF(6))(2) and [Ru(bpy)(2)(bpy-CM343)](PF(6))(2) (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coumarins / chemistry*
  • Drug Screening Assays, Antitumor
  • Energy Transfer
  • Esterases / metabolism*
  • Hep G2 Cells
  • Humans
  • Luminescence
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology
  • Ruthenium / chemistry*
  • Swine

Substances

  • Coumarins
  • Organometallic Compounds
  • Ruthenium
  • Esterases