Abstract
Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
Keywords:
Streptomyces lusitanus; antibacterial; antimycin B; marine-derived actinomycete.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / pharmacology*
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Antimycin A / analogs & derivatives*
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Antimycin A / biosynthesis
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Antimycin A / pharmacology*
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Aquatic Organisms
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Bacteria / drug effects
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Chromatography, High Pressure Liquid
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Culture Media
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Indicators and Reagents
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Lactones / chemistry
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Conformation
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Spectrophotometry, Ultraviolet
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Streptomyces / genetics
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Streptomyces / growth & development
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Streptomyces / metabolism*
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Threonine / chemistry
Substances
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Anti-Bacterial Agents
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Culture Media
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Indicators and Reagents
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Lactones
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antimycin B1
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antimycin B2
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Threonine
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Antimycin A