Solid-phase parallel synthesis of drug-like artificial 2H-benzopyran libraries

Taeho Lee; Young-Dae Gong

doi:10.3390/molecules17055467

Solid-phase parallel synthesis of drug-like artificial 2H-benzopyran libraries

Molecules. 2012 May 9;17(5):5467-96. doi: 10.3390/molecules17055467.

Authors

Taeho Lee¹, Young-Dae Gong

Affiliation

¹ Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Buk-gu, Daegu, Korea. tlee@knu.ac.kr

Abstract

This review covers the construction of drug-like 2H-benzopyrans and related libraries using solid-phase parallel synthesis. In this context, the preparation of substituted benzopyrans such as mono-, di- and trisubstituted benzopyran derivatives and additional ring-fused benzopyrans such as benzopyranoisoxazoles, benzopyranopyrazoles, six-membered ring-fused benzopyrans, and polycyclic benzopyrans are highlighted.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Benzopyrans / chemical synthesis*
Combinatorial Chemistry Techniques
Drug Discovery
Molecular Structure
Pharmaceutical Preparations
Small Molecule Libraries / chemical synthesis*
Solid-Phase Synthesis Techniques / methods*

Substances

Benzopyrans
Pharmaceutical Preparations
Small Molecule Libraries