Organogold(III) supramolecular polymers for anticancer treatment

Jing-Jing Zhang; Wei Lu; Raymond Wai-Yin Sun; Chi-Ming Che

doi:10.1002/anie.201108466

Organogold(III) supramolecular polymers for anticancer treatment

Angew Chem Int Ed Engl. 2012 May 14;51(20):4882-6. doi: 10.1002/anie.201108466. Epub 2012 Apr 4.

Authors

Jing-Jing Zhang¹, Wei Lu, Raymond Wai-Yin Sun, Chi-Ming Che

Affiliation

¹ State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong, China.

PMID: 22473661
DOI: 10.1002/anie.201108466

Abstract

Gold cures: the depicted gold(III) complex self-assembles into supramolecular polymers which form nanofibrillar networks that display sustained cytotoxicity and can also act as carriers for other cytotoxic agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Melanoma / drug therapy
Melanoma, Experimental / drug therapy
Mice
Organogold Compounds / chemistry
Organogold Compounds / pharmacology*
Porphyrins / chemistry
Porphyrins / pharmacology
Pyridines / chemistry
Pyridines / pharmacology
Spectrophotometry, Ultraviolet

Substances

Antineoplastic Agents
Organogold Compounds
Porphyrins
Pyridines