Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Olivia T W Ng; L W Chen; Y S Chan; Ken K L Yung

doi:10.1159/000334720

Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Neurosignals. 2013;21(1-2):42-54. doi: 10.1159/000334720. Epub 2012 Feb 23.

Authors

Olivia T W Ng¹, L W Chen, Y S Chan, Ken K L Yung

Affiliation

¹ Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.

PMID: 22377595
DOI: 10.1159/000334720

Abstract

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos ameliorated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Dopaminergic Neurons / metabolism*
Dopaminergic Neurons / pathology
Enzyme Activation / physiology
MAP Kinase Signaling System / physiology*
Male
Neuroprotective Agents / metabolism*
Parkinsonian Disorders / metabolism
Parkinsonian Disorders / pathology
Parkinsonian Disorders / prevention & control
RNA, Small Interfering / biosynthesis*
RNA, Small Interfering / genetics
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / biosynthesis*
Receptors, N-Methyl-D-Aspartate / genetics

Substances

NR2B NMDA receptor
Neuroprotective Agents
RNA, Small Interfering
Receptors, N-Methyl-D-Aspartate