Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons

Hong Kong Med J. 2012 Feb:18 Suppl 2:42-4.

Abstract

1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2. Minocycline but not memantine or glycoconjugate protected cultured cells and warrants further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Anti-Bacterial Agents / pharmacology*
  • Apoptosis
  • Caspase 3 / metabolism
  • Cell Line, Tumor
  • Encephalitis, Japanese / complications
  • Excitatory Amino Acid Antagonists / pharmacology
  • Glycoconjugates / pharmacology
  • Humans
  • L-Lactate Dehydrogenase / metabolism
  • Memantine / pharmacology
  • Minocycline / pharmacology*
  • Neurons / drug effects
  • Neurons / enzymology
  • Neurons / pathology
  • Neuroprotective Agents / pharmacology*
  • Neurotoxicity Syndromes / enzymology
  • Neurotoxicity Syndromes / etiology
  • Neurotoxicity Syndromes / prevention & control*
  • RNA, Double-Stranded

Substances

  • Anti-Bacterial Agents
  • Excitatory Amino Acid Antagonists
  • Glycoconjugates
  • Neuroprotective Agents
  • RNA, Double-Stranded
  • L-Lactate Dehydrogenase
  • Caspase 3
  • Minocycline
  • Memantine