Abstract
1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2. Minocycline but not memantine or glycoconjugate protected cultured cells and warrants further investigation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Anti-Bacterial Agents / pharmacology*
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Apoptosis
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Caspase 3 / metabolism
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Cell Line, Tumor
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Encephalitis, Japanese / complications
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Excitatory Amino Acid Antagonists / pharmacology
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Glycoconjugates / pharmacology
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Humans
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L-Lactate Dehydrogenase / metabolism
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Memantine / pharmacology
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Minocycline / pharmacology*
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Neurons / drug effects
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Neurons / enzymology
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Neurons / pathology
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Neuroprotective Agents / pharmacology*
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Neurotoxicity Syndromes / enzymology
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Neurotoxicity Syndromes / etiology
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Neurotoxicity Syndromes / prevention & control*
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RNA, Double-Stranded
Substances
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Anti-Bacterial Agents
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Excitatory Amino Acid Antagonists
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Glycoconjugates
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Neuroprotective Agents
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RNA, Double-Stranded
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L-Lactate Dehydrogenase
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Caspase 3
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Minocycline
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Memantine