XCL1 and XCR1 in the immune system

Yu Lei; Yousuke Takahama

doi:10.1016/j.micinf.2011.10.003

XCL1 and XCR1 in the immune system

Microbes Infect. 2012 Mar;14(3):262-7. doi: 10.1016/j.micinf.2011.10.003. Epub 2011 Oct 31.

Authors

Yu Lei¹, Yousuke Takahama

Affiliation

¹ Key Laboratory of Molecular Biology for Infectious Disease, People's Republic of China Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.

PMID: 22100876
DOI: 10.1016/j.micinf.2011.10.003

Abstract

XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response. It has been also shown that XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells. This review summarizes the expression and function of XCL1 and XCR1 in the immune system.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / immunology
CD8-Positive T-Lymphocytes / immunology
Chemokines, C / genetics
Chemokines, C / immunology*
Cytotoxicity, Immunologic
Dendritic Cells / immunology
Gene Expression Regulation / immunology
Humans
Receptors, Chemokine / immunology*
Receptors, G-Protein-Coupled / genetics
Receptors, G-Protein-Coupled / immunology*
Self Tolerance
Spleen / cytology
Spleen / immunology
T-Lymphocytes, Regulatory / immunology
Thymus Gland / cytology
Thymus Gland / immunology

Substances

Chemokines, C
Receptors, Chemokine
Receptors, G-Protein-Coupled
XC chemokine receptor 1, mouse
XCL1 protein, human
XCR1 protein, human
Xcl1 protein, mouse