Gold-mediated bifunctional modification of oligosaccharides via a three-component coupling reaction

Org Biomol Chem. 2012 Feb 7;10(5):925-30. doi: 10.1039/c1ob06429k. Epub 2011 Nov 10.

Abstract

An efficient modular approach for single-site incorporation of two independent functionalities (amines and alkynes) into aldehyde-containing oligosaccharides concurrently by using a one-pot gold-mediated three-component coupling reaction in aqueous medium under mild conditions has been developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Alkynes / chemistry*
  • Amines / chemistry*
  • Gold / chemistry*
  • Oligosaccharides / chemistry*

Substances

  • Aldehydes
  • Alkynes
  • Amines
  • Oligosaccharides
  • Gold