Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Adv Mater. 2011 Dec 22;23(48):5785-91. doi: 10.1002/adma.201103463. Epub 2011 Nov 8.

Abstract

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Biomimetics
  • Cell Differentiation
  • Cells, Cultured
  • Embryonic Stem Cells / cytology*
  • Equipment Design
  • Flow Cytometry / methods
  • Humans
  • Materials Testing
  • Mice
  • Myocardium / cytology*
  • Myocytes, Cardiac / cytology*
  • Rats
  • Stem Cells / cytology
  • Surface Properties