Adrenomedullin enhances the progressive motility and zona pellucida-binding capacity of spermatozoa from normozoospermic but not asthenozoospermic men

Mol Reprod Dev. 2012 Feb;79(2):76. doi: 10.1002/mrd.21398. Epub 2011 Oct 11.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenomedullin / pharmacology*
  • Asthenozoospermia / metabolism
  • Asthenozoospermia / pathology*
  • Calcitonin Gene-Related Peptide / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Humans
  • Male
  • Peptide Fragments / pharmacology
  • Receptor Activity-Modifying Protein 1 / metabolism
  • Receptor Activity-Modifying Protein 2 / metabolism
  • Receptor Activity-Modifying Protein 3 / metabolism
  • Sperm Motility / drug effects*
  • Spermatozoa / drug effects*
  • Spermatozoa / metabolism
  • Spermatozoa / pathology
  • Spermatozoa / physiology
  • Up-Regulation / drug effects
  • Zona Pellucida / drug effects*
  • Zona Pellucida / metabolism

Substances

  • Peptide Fragments
  • RAMP1 protein, human
  • RAMP2 protein, human
  • RAMP3 protein, human
  • Receptor Activity-Modifying Protein 1
  • Receptor Activity-Modifying Protein 2
  • Receptor Activity-Modifying Protein 3
  • adrenomedullin (22-52)
  • calcitonin gene-related peptide (8-37)
  • Adrenomedullin
  • Calcitonin Gene-Related Peptide