A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection

Behav Genet. 2011 Sep;41(5):776-9. doi: 10.1007/s10519-011-9475-0. Epub 2011 May 29.

Abstract

Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Epistasis, Genetic
  • Genetics*
  • Genotype
  • Humans
  • Models, Genetic
  • Models, Statistical
  • Phenotype
  • Quantitative Trait, Heritable*
  • Regression Analysis
  • Reproducibility of Results