Anticancer gold(I)-phosphine complexes as potent autophagy-inducing agents

Chem Commun (Camb). 2011 Sep 7;47(33):9318-20. doi: 10.1039/c1cc11820j. Epub 2011 May 16.

Abstract

A panel of anticancer gold(I)-phosphine complexes exhibit significant autophagy-inducing properties in cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity
  • Autophagy / drug effects*
  • Cell Line, Tumor
  • Coordination Complexes / chemistry*
  • Coordination Complexes / toxicity
  • Drug Screening Assays, Antitumor
  • Gold / chemistry*
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Phosphines / chemistry*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • MAP1LC3A protein, human
  • Microtubule-Associated Proteins
  • Phosphines
  • Gold
  • phosphine