Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone

Life Sci. 1990;46(23):1643-8. doi: 10.1016/0024-3205(90)90378-5.

Abstract

Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Analysis of Variance
  • Animals
  • Buspirone / pharmacology*
  • Dietary Carbohydrates / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Eating / drug effects
  • Fluoxetine / pharmacology
  • Food Preferences / drug effects*
  • Male
  • Naphthalenes / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Tetrahydronaphthalenes / pharmacology*

Substances

  • Dietary Carbohydrates
  • Naphthalenes
  • Tetrahydronaphthalenes
  • Fluoxetine
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Buspirone