Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

Angew Chem Int Ed Engl. 2011 Mar 7;50(11):2554-8. doi: 10.1002/anie.201006887. Epub 2011 Feb 18.

Authors

Ping Wang¹, Chung-Hang Leung, Dik-Lung Ma, Raymond Wai-Yin Sun, Siu-Cheong Yan, Qing-Shou Chen, Chi-Ming Che

Affiliation

¹ Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, P.R. China.

PMID: 21370336
DOI: 10.1002/anie.201006887

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Base Sequence
Cyclic AMP Response Element-Binding Protein / chemistry
Cyclic AMP Response Element-Binding Protein / drug effects
Cyclic AMP Response Element-Binding Protein / metabolism*
Cyclization
DNA / chemistry*
DNA / metabolism*
Molecular Sequence Data
Molecular Structure
Organometallic Compounds / chemistry*
Organometallic Compounds / pharmacology
Platinum / chemistry*
Protein Binding / drug effects
Thermodynamics

Substances

Antineoplastic Agents
Cyclic AMP Response Element-Binding Protein
Organometallic Compounds
Platinum
DNA