Abstract
Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.
Publication types
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Randomized Controlled Trial
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Apoptosis / drug effects
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Body Weight / drug effects*
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Cachexia / drug therapy*
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Cachexia / etiology
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Colorectal Neoplasms / complications
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / metabolism
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Combined Modality Therapy
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Curcumin / therapeutic use*
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Digestive System Surgical Procedures
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Double-Blind Method
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunohistochemistry
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In Situ Nick-End Labeling
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Male
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Neoplasm Staging
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Radiotherapy
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Tumor Necrosis Factor-alpha / blood
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Tumor Suppressor Protein p53 / drug effects
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Tumor Suppressor Protein p53 / metabolism*
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Up-Regulation
Substances
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Antineoplastic Agents
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Tumor Necrosis Factor-alpha
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Tumor Suppressor Protein p53
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Curcumin