"Proof-of-principle" concept for label-free detection of glucose and α-glucosidase activity through the electrostatic assembly of alkynylplatinum(II) terpyridyl complexes

Clive Yik-Sham Chung; Kenneth Hoi-Yiu Chan; Vivian Wing-Wah Yam

doi:10.1039/c0cc04437g

"Proof-of-principle" concept for label-free detection of glucose and α-glucosidase activity through the electrostatic assembly of alkynylplatinum(II) terpyridyl complexes

Chem Commun (Camb). 2011 Feb 21;47(7):2000-2. doi: 10.1039/c0cc04437g. Epub 2011 Jan 12.

Authors

Clive Yik-Sham Chung¹, Kenneth Hoi-Yiu Chan, Vivian Wing-Wah Yam

Affiliation

¹ Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.

PMID: 21229140
DOI: 10.1039/c0cc04437g

Abstract

A two-component platinum(II) complex-polymer ensemble has been demonstrated for label-free spectroscopic detection of glucose and α-glucosidase activity, based on the electrostatic assembly of cationic platinum(II) complex molecules onto a glucose-bound anionic polymer.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Boronic Acids / chemistry
Glucose / analysis*
Glycogen Storage Disease Type II / diagnosis
Humans
Organoplatinum Compounds / chemistry*
Pyridines / chemistry
Sensitivity and Specificity
Spectrophotometry / methods*
Static Electricity
alpha-Glucosidases / metabolism*

Substances

Boronic Acids
Organoplatinum Compounds
Pyridines
alpha-Glucosidases
Glucose