Osmium(VI) complexes as a new class of potential anti-cancer agents

Chem Commun (Camb). 2011 Feb 21;47(7):2140-2. doi: 10.1039/c0cc04515b. Epub 2011 Jan 4.

Abstract

A nitridoosmium(VI) complex [Os(VI)(N)(sap)(OH(2))Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Cell Cycle / drug effects
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Neoplasms / drug therapy
  • Osmium Compounds / chemistry*
  • Osmium Compounds / pharmacology*

Substances

  • Antineoplastic Agents
  • Osmium Compounds