Abstract
A nitridoosmium(VI) complex [Os(VI)(N)(sap)(OH(2))Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Cycle / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Neoplasms / drug therapy
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Osmium Compounds / chemistry*
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Osmium Compounds / pharmacology*
Substances
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Antineoplastic Agents
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Osmium Compounds