Abstract
Seven carbapenem-resistant NDM-1-positive Klebsiella pneumoniae isolates were recovered from patients hospitalized between 2007 and 2009 in different wards at a referral and tertiary care center in Nairobi. Most of the isolates were obtained from urine. All isolates carried the bla(NDM-1) carbapenemase gene previously reported from India, Pakistan, and the United Kingdom. These isolates were clonally related and expressed many other resistance determinants, including β-lactamases CTX-M-15, OXA-1, OXA-9, CMY-6, and aminoglycoside resistance methylase RmtC. This work corresponds to the first report of NDM-1 producers in Africa.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / pharmacology*
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Cross Infection / epidemiology
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Cross Infection / microbiology
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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Female
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Humans
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Kenya / epidemiology
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification*
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Polymerase Chain Reaction
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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beta-Lactamases
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beta-lactamase NDM-1