Aptamer-induced self-assembly of a NIR-emissive platinum(II) terpyridyl complex for label- and immobilization-free detection of lysozyme and thrombin

Margaret Ching-Lam Yeung; Keith Man-Chung Wong; Yuk Kai Tiu Tsang; Vivian Wing-Wah Yam

doi:10.1039/c0cc02631j

Aptamer-induced self-assembly of a NIR-emissive platinum(II) terpyridyl complex for label- and immobilization-free detection of lysozyme and thrombin

Chem Commun (Camb). 2010 Nov 7;46(41):7709-11. doi: 10.1039/c0cc02631j. Epub 2010 Sep 24.

Authors

Margaret Ching-Lam Yeung¹, Keith Man-Chung Wong, Yuk Kai Tiu Tsang, Vivian Wing-Wah Yam

Affiliation

¹ Institute of Molecular Functional Materials (Areas of Excellence Scheme, University Grants Committee, Hong Kong) and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.

PMID: 20871876
DOI: 10.1039/c0cc02631j

Abstract

With the aptamer-induced self-assembly feature of NIR-emissive platinum(ii) terpyridyl complex, a "proof-of-principle" concept in label- and immobilization-free probing strategies of lysozyme and thrombin has been demonstrated with good selectivity and specificity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aptamers, Nucleotide / metabolism*
Biosensing Techniques / methods*
Enzymes, Immobilized / analysis
Enzymes, Immobilized / chemistry
Enzymes, Immobilized / metabolism
Muramidase / analysis*
Muramidase / chemistry
Muramidase / metabolism
Organoplatinum Compounds / chemistry*
Spectrophotometry, Infrared
Substrate Specificity
Thrombin / analysis*
Thrombin / chemistry
Thrombin / metabolism

Substances

Aptamers, Nucleotide
Enzymes, Immobilized
Organoplatinum Compounds
Muramidase
Thrombin