Abstract
A multidrug-resistant Escherichia coli isolate recovered in Australia produced a carbapenem-hydrolyzing β-lactamase. Molecular investigations revealed the first identification of the bla(NDM-1) metallo-β-lactamase gene in that country. In addition, this E. coli isolate expressed the extended-spectrum β-lactamase CTX-M-15, together with two 16S rRNA methylases, namely, ArmA and RmtB, conferring a high level of resistance to aminoglycosides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Australia
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Drug Resistance, Multiple, Bacterial / genetics
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Escherichia coli / drug effects*
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli Proteins / genetics
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Methyltransferases / genetics
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Microbial Sensitivity Tests
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Polymerase Chain Reaction
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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beta-Lactams
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ArmA protein, E coli
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Methyltransferases
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RmtB protein, E coli
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beta-Lactamases
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beta-lactamase NDM-1