Emergence of metallo-β-lactamase NDM-1-producing multidrug-resistant Escherichia coli in Australia

Antimicrob Agents Chemother. 2010 Nov;54(11):4914-6. doi: 10.1128/AAC.00878-10. Epub 2010 Sep 7.

Abstract

A multidrug-resistant Escherichia coli isolate recovered in Australia produced a carbapenem-hydrolyzing β-lactamase. Molecular investigations revealed the first identification of the bla(NDM-1) metallo-β-lactamase gene in that country. In addition, this E. coli isolate expressed the extended-spectrum β-lactamase CTX-M-15, together with two 16S rRNA methylases, namely, ArmA and RmtB, conferring a high level of resistance to aminoglycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents
  • Australia
  • Drug Resistance, Multiple, Bacterial / genetics
  • Escherichia coli / drug effects*
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Escherichia coli Proteins / genetics
  • Methyltransferases / genetics
  • Microbial Sensitivity Tests
  • Polymerase Chain Reaction
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • beta-Lactams
  • ArmA protein, E coli
  • Methyltransferases
  • RmtB protein, E coli
  • beta-Lactamases
  • beta-lactamase NDM-1