A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery

J Clin Periodontol. 2010 Nov;37(11):988-97. doi: 10.1111/j.1600-051X.2010.01609.x. Epub 2010 Aug 25.

Abstract

Background: Chlorhexidine (CHX) rinsing after periodontal surgery is common. We assessed the clinical and microbiological effects of two CHX concentrations following periodontal surgery.

Materials and methods: In a randomized, controlled clinical trial, 45 subjects were assigned to 4 weeks rinsing with a 0.05 CHX/herbal extract combination (test) or a 0.1% CHX solution. Clinical and staining effects were studied. Subgingival bacteria were assessed using the DNA-DNA checkerboard. Statistics included parametric and non-parametric tests (p<0001 to declare significance at 80% power).

Results: At weeks 4 and 12, more staining was found in the control group (p<0.05 and p<0.001, respectively). A higher risk for staining was found in the control group (crude OR: 2.3:1, 95% CI: 1.3 to 4.4, p<0.01). The absolute staining reduction in the test group was 21.1% (9 5% CI: 9.4-32.8%). Probing pocket depth (PPD) decreases were significant (p<0.001) in both groups and similar (p=0.92). No rinse group differences in changes of bacterial counts for any species were found between baseline and week 12.

Conclusions: The test CHX rinse resulted in less tooth staining. At the study endpoint, similar and high counts of periodontal pathogens were found.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Infective Agents, Local / administration & dosage*
  • Anti-Infective Agents, Local / adverse effects
  • Bacterial Load / drug effects*
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / adverse effects
  • Chlorhexidine / analogs & derivatives*
  • Chronic Periodontitis / drug therapy*
  • Chronic Periodontitis / microbiology
  • Chronic Periodontitis / surgery
  • Colony Count, Microbial
  • DNA, Bacterial / analysis
  • Dental Plaque / microbiology
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Logistic Models
  • Male
  • Mentha piperita
  • Middle Aged
  • Mouthwashes / adverse effects
  • Mouthwashes / chemistry
  • Mouthwashes / therapeutic use*
  • Odds Ratio
  • Periodontal Debridement
  • Phytotherapy*
  • Plant Oils / therapeutic use
  • Plant Preparations / therapeutic use*
  • Salvia
  • Sodium Fluoride / therapeutic use
  • Statistics, Nonparametric
  • Terpenes / therapeutic use
  • Tooth Discoloration / chemically induced

Substances

  • Anti-Infective Agents, Local
  • DNA, Bacterial
  • Drug Combinations
  • Mouthwashes
  • Plant Oils
  • Plant Preparations
  • Terpenes
  • Sodium Fluoride
  • peppermint oil
  • myrrh oil
  • chlorhexidine gluconate
  • Chlorhexidine