Regulatory T cell immunotherapy for transplantation tolerance: step into clinic

Int Immunopharmacol. 2010 Dec;10(12):1486-90. doi: 10.1016/j.intimp.2010.08.007. Epub 2010 Aug 22.

Abstract

Recent studies in animal models have demonstrated that adoptive transfer of antigen-specific CD4+CD25+ regulatory T cells (Tregs) can prevent or even cure autoimmune diseases, and appear to induce transplantation tolerance. Thus, adoptive cell therapy using ex vivo induced and expanded patient-specific CD4+CD25+Tregs has emerged as a promising individualized medicine for the treatment of inflammatory disease. Here we discuss our current efforts on the pursuit of regulatory T cell therapy for the induction of transplantation tolerance.

MeSH terms

  • Adoptive Transfer / methods*
  • Animals
  • Antigen-Presenting Cells / immunology
  • CD4 Antigens / immunology
  • Cell Communication / immunology
  • Clinical Trials, Phase I as Topic
  • Graft vs Host Disease / immunology
  • Graft vs Host Disease / therapy*
  • Humans
  • Interleukin-2 Receptor alpha Subunit / immunology
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / transplantation*
  • Transplantation Tolerance / immunology*

Substances

  • CD4 Antigens
  • Interleukin-2 Receptor alpha Subunit