SCID mice as immune system models

Curr Opin Immunol. 1991 Apr;3(2):224-8. doi: 10.1016/0952-7915(91)90055-6.

Abstract

C.B-17 scid/scid mice are born with severe combined immunodeficiency. This defect in the maturation of T and B cells has provided a novel experimental system in which to study normal lymphoid differentiation and function in mouse and man.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Hematopoietic System / immunology
  • Humans
  • Immune System*
  • Lymphoid Tissue / immunology
  • Mice
  • Mice, Mutant Strains / genetics
  • Mice, Mutant Strains / immunology*
  • Models, Biological