Encapsulation of dual cytotoxic and anti-angiogenic gold(III) complexes by gelatin-acacia microcapsules: in vitro and in vivo studies

Jessie Jing Yan; Raymond Wai-Yin Sun; Peng Wu; Marie C M Lin; Albert S-C Chan; Chi-Ming Che

doi:10.1039/c003044a

Encapsulation of dual cytotoxic and anti-angiogenic gold(III) complexes by gelatin-acacia microcapsules: in vitro and in vivo studies

Dalton Trans. 2010 Sep 7;39(33):7700-5. doi: 10.1039/c003044a. Epub 2010 Jul 23.

Authors

Jessie Jing Yan¹, Raymond Wai-Yin Sun, Peng Wu, Marie C M Lin, Albert S-C Chan, Chi-Ming Che

Affiliation

¹ Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

PMID: 20652177
DOI: 10.1039/c003044a

Abstract

Encapsulation of the anticancer gold(III) complexes bearing porphyrin or Schiff-base ligands by gelatin-acacia microcapsules confers both sustained-release and rapid-release properties, improved solution stability and/or in vivo efficacy compared to that using the unencapsulated complexes alone.

MeSH terms

Acacia
Angiogenesis Inhibitors / chemical synthesis*
Angiogenesis Inhibitors / chemistry
Angiogenesis Inhibitors / pharmacology*
Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Capsules
Cell Line, Tumor
Drug Compounding
Drug Screening Assays, Antitumor
Gelatin
Humans
Metalloporphyrins / chemical synthesis*
Metalloporphyrins / chemistry
Metalloporphyrins / pharmacology*
Mice
Mice, Nude
Particle Size

Substances

Angiogenesis Inhibitors
Antineoplastic Agents
Capsules
Metalloporphyrins
gold (III) porphyrin 1a
Gelatin