Pseudolaric acids: isolation, bioactivity and synthetic studies

Nat Prod Rep. 2010 Jul;27(7):1066-83. doi: 10.1039/b906520m. Epub 2010 Apr 20.

Abstract

The pseudolaric acids are diterpenoids isolated from the root bark of Pseudolarix amabilis, or the golden larch. Pseudolaric acids A and B are the major antifungal and anti-angiogenic congeners of this family of compounds. This review presents the results of the isolation, biological and synthetic studies of these natural products. 127 references are cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors
  • Anti-Infective Agents
  • Antineoplastic Agents, Phytogenic
  • Biological Products* / chemical synthesis
  • Biological Products* / chemistry
  • Biological Products* / isolation & purification
  • Biological Products* / pharmacology
  • Contraceptive Agents
  • Diterpenes* / chemical synthesis
  • Diterpenes* / chemistry
  • Diterpenes* / isolation & purification
  • Diterpenes* / pharmacology
  • Drugs, Chinese Herbal* / chemical synthesis
  • Drugs, Chinese Herbal* / chemistry
  • Drugs, Chinese Herbal* / isolation & purification
  • Drugs, Chinese Herbal* / pharmacology
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Angiogenesis Inhibitors
  • Anti-Infective Agents
  • Antineoplastic Agents, Phytogenic
  • Biological Products
  • Contraceptive Agents
  • Diterpenes
  • Drugs, Chinese Herbal
  • pseudolaric acid B
  • pseudolaric acid A