Abstract
Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Products / chemistry
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Biological Products / pharmacology
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DNA / chemistry
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G-Quadruplexes*
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Heterocyclic Compounds, 3-Ring / chemistry*
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Heterocyclic Compounds, 3-Ring / pharmacology
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High-Throughput Screening Assays
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Ligands
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Models, Molecular
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Nucleic Acid Conformation
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Proto-Oncogene Proteins c-myc / genetics*
Substances
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Biological Products
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Heterocyclic Compounds, 3-Ring
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Ligands
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Proto-Oncogene Proteins c-myc
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fonsecin B
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DNA