Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

Ching Tung Lum; Xiong Liu; Raymond Wai-Yin Sun; Xiang-Ping Li; Ying Peng; Ming-Liang He; Hsiang Fu Kung; Chi-Ming Che; Marie C M Lin

doi:10.1016/j.canlet.2010.01.033

Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

Cancer Lett. 2010 Aug 28;294(2):159-66. doi: 10.1016/j.canlet.2010.01.033. Epub 2010 Feb 16.

Authors

Ching Tung Lum¹, Xiong Liu, Raymond Wai-Yin Sun, Xiang-Ping Li, Ying Peng, Ming-Liang He, Hsiang Fu Kung, Chi-Ming Che, Marie C M Lin

Affiliation

¹ Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

PMID: 20163914
DOI: 10.1016/j.canlet.2010.01.033

Abstract

A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis / drug effects
Cell Growth Processes / drug effects
Cell Line, Tumor
Cell Movement / drug effects*
Down-Regulation / drug effects
Gene Expression Profiling
Gold / pharmacology*
Humans
Immunohistochemistry
Liver Neoplasms, Experimental / prevention & control
Liver Neoplasms, Experimental / secondary
Lung Neoplasms / prevention & control
Lung Neoplasms / secondary
Male
Metalloporphyrins / pharmacology*
Mice
Mice, Inbred BALB C
Mice, Nude
Monoacylglycerol Lipases / biosynthesis
Monoacylglycerol Lipases / genetics
Nasopharyngeal Neoplasms / blood supply
Nasopharyngeal Neoplasms / drug therapy*
Nasopharyngeal Neoplasms / enzymology
Nasopharyngeal Neoplasms / pathology
Neovascularization, Pathologic / drug therapy
Neovascularization, Pathologic / pathology
RNA, Messenger / biosynthesis
RNA, Messenger / genetics
Rats
Xenograft Model Antitumor Assays

Substances

Metalloporphyrins
RNA, Messenger
gold (III) porphyrin 1a
Gold
Monoacylglycerol Lipases