Failure of a glass ionomer to remineralize apatite-depleted dentin

J Dent Res. 2010 Mar;89(3):230-5. doi: 10.1177/0022034509357172. Epub 2010 Jan 28.

Abstract

Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IX(GP), and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1-4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Apatites / administration & dosage
  • Apatites / chemistry
  • Dental Restoration Failure
  • Dental Restoration, Permanent / methods*
  • Dentin / drug effects*
  • Glass Ionomer Cements / chemistry
  • Glass Ionomer Cements / therapeutic use*
  • Humans
  • Tooth Demineralization / therapy*
  • Tooth Remineralization / methods*

Substances

  • Apatites
  • Fuji IX GP Fast
  • Glass Ionomer Cements