Abstract
This paper summarises how scaffold proteins affects and regulate the JNK signalling pathway. We believe that some of these scaffold proteins, by virtue of their anchoring and catalytic properties contribute to a high degree of specificity of intra cellular signalling pathways that regulate the progression through the cell cycle.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism
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Adaptor Proteins, Signal Transducing / physiology*
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Animals
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Apoptosis
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JNK Mitogen-Activated Protein Kinases / metabolism*
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MAP Kinase Kinase Kinases / metabolism
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MAP Kinase Kinase Kinases / physiology
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MAP Kinase Signaling System*
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Mice
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Mice, Knockout
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Nerve Tissue Proteins / physiology
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Saccharomyces cerevisiae Proteins / physiology
Substances
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Adaptor Proteins, Signal Transducing
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Mapk8ip protein, mouse
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Mapk8ip2 protein, mouse
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Mapk8ip3 protein, mouse
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Nerve Tissue Proteins
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STE5 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Spag9 protein, mouse
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JNK Mitogen-Activated Protein Kinases
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MAP Kinase Kinase Kinases