Single nucleotide polymorphisms of complement component 5 and periodontitis

J Periodontal Res. 2010 Jun;45(3):301-8. doi: 10.1111/j.1600-0765.2009.01234.x. Epub 2009 Nov 9.

Abstract

Background and objective: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population.

Material and methods: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system.

Results: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006).

Conclusion: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine
  • Adolescent
  • Adult
  • Age Factors
  • Aggressive Periodontitis / genetics
  • Aggressive Periodontitis / immunology
  • Case-Control Studies
  • Chronic Periodontitis / genetics
  • Chronic Periodontitis / immunology
  • Complement C5 / genetics*
  • Cytosine
  • Female
  • Gene Frequency / genetics
  • Genetic Variation / genetics
  • Genotype
  • Guanine
  • Haplotypes
  • Hong Kong
  • Humans
  • Immunologic Factors / genetics*
  • Introns / genetics
  • Linkage Disequilibrium / genetics
  • Male
  • Middle Aged
  • Periodontitis / genetics
  • Periodontitis / immunology*
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • Sex Factors
  • Smoking
  • Young Adult

Substances

  • Complement C5
  • Immunologic Factors
  • Guanine
  • Cytosine
  • Adenine