Possible olanzapine-induced hepatotoxicity in a young Chinese patient

S Y Lui; Steve Tso; M Lam; Eric F C Cheung

Possible olanzapine-induced hepatotoxicity in a young Chinese patient

Hong Kong Med J. 2009 Oct;15(5):394-6.

Authors

S Y Lui¹, Steve Tso, M Lam, Eric F C Cheung

Affiliation

¹ Castle Peak Hospital, Tuen Mun, Hong Kong. simonsylui@yahoo.com.hk

PMID: 19801701

Abstract

We present a case of a 17-year-old man with first-episode schizophrenia who developed olanzapine-induced hepatitis, cholestasis, and splenomegaly, all of which were reversed after ceasing olanzapine. Clinicians prescribing olanzapine should be aware of this possible hepatotoxicity. Patient education, vigilance from clinicians, and careful clinical examination can help detect this complication early.

Publication types

Case Reports

MeSH terms

Adolescent
Antipsychotic Agents / adverse effects*
Antipsychotic Agents / therapeutic use
Benzodiazepines / adverse effects*
Benzodiazepines / therapeutic use
Chemical and Drug Induced Liver Injury / etiology*
China
Cholestasis / chemically induced
Humans
Male
Olanzapine
Schizophrenia / drug therapy
Splenomegaly / chemically induced

Substances

Antipsychotic Agents
Benzodiazepines
Olanzapine